Studies on the Metabolism of Naturally Occurring Coumarins. II. Urinary Metabolites of Umbelliferone.

The metabolic fate of umbelliferone was studied by the quantitative analysis of urinary excrete of rabbits. The orally administered umbelliferone was converted into glucuronide (44.32%) and ethereal sulfate (19.10%) accompanying unchanged umbelliferone (20.23%). An extractor of high efficiency was designed to be employed for the continuous extraction of urinary metabolites.