[Association of hs-CRP with frailty and its components among the elderly over 65 years old in 9 longevity areas of China].

Objective: To investigate the association of the levels of high sensitivity C-reactive protein (hs-CRP) with frailty and its components among the elderly over 65 years old in 9 longevity areas of China. Methods: Cross-sectional data from the Health Ageing and Biomarkers Cohort Study (HABCS, 2017-2018) were used and the elderly over 65 years old were included in this study. Through questionnaire interview and physical examination, the information including demographic characteristics, behavior, diet, daily activity, cognitive function, and health status was collected. The association between hs-CRP and frailty and its components in the participants was analyzed by multivariate logistic regression model and restrictive cubic spline. Results: A total of 2 453 participants were finally included, the age was (84.8±19.8) years old. The median hs-CRP level was 1.13 mg/L and the prevalence of frailty was 24.4%. Compared with the low-level group (hs-CRP<1.0 mg/L), the OR (95%CI) value of the high-level group (hs-CRP>3.0 mg/L) was 1.79 (1.35-2.36) mg/L. As for the components, the hs-CRP level was also positively associated with ADL disability, IADL disability, functional limitation and multimorbidity. After adjusting for confounding factors, compared with the low-level group, the OR (95%CI) values of the high-level group for the four components were 1.68 (1.25-2.27), 1.88 (1.42-2.50), 1.68 (1.31-2.14) and 1.39 (1.12-1.72), respectively. Conclusion: There is a positive association between the levels of hs-CRP and the risk of frailty among the elderly over 65 years old in 9 longevity areas of China. The higher hs-CRP level may increase the risk of frailty by elevating the risk of four physical functional disabilities, namely ADL disability, IADL disability, functional limitation and multimorbidity.目的： 研究中国9个长寿地区≥65岁老年人超敏C反应蛋白水平（hs-CRP）与虚弱及其组分的关联。 方法： 利用“老年健康生物标志物队列研究”项目中2017—2018年的横断面数据，将≥65岁老年人纳入研究。通过问卷调查和体格检查，收集调查对象的人口学特征、行为方式、膳食情况、日常活动能力、认知功能、自我健康状况、现患疾病情况等信息。采用多因素logistic回归模型和限制性立方样条分析老年人hs-CRP与虚弱及其组分的关联。 结果： 本研究共纳入2 453名研究对象，年龄为（84.8±19.8）岁，hs-CRP水平的中位数为1.13 mg/L；虚弱的患病率为24.4%（598/2 453）。调整混杂因素后，与低水平组（hs-CRP<1.0 mg/L）相比，高水平组（hs-CRP>3.0 mg/L）OR（95%CI）值为1.79（1.35~2.36）。调整混杂因素后，对hs-CRP水平与虚弱各组分的多因素logistic回归模型分析结果显示，与低水平组相比，日常生活自理能力（ADL）受损、器具性日常生活自理能力（IADL）受损、功能限制、共病在高水平组OR（95%CI）值分别为1.68（1.25~2.27）、1.88（1.42~2.50）、1.68（1.31~2.14）和1.39（1.12~1.72）。 结论： 中国9个长寿地区≥65岁老年人hs-CRP水平与虚弱风险存在正向关联，较高的hs-CRP水平可能通过增加ADL受损、IADL受损、功能限制和共病，从而增加老年人的虚弱风险。.