转录因子
福克斯O1
生物
细胞生物学
巨噬细胞
癌变
功能(生物学)
免疫系统
先天免疫系统
吞噬作用
叉头转录因子
基因表达调控
癌症研究
免疫学
基因
遗传学
体外
作者
Shan Jie Rong,Yang Chun,Faxi Wang,Fei Sun,Jia Hui Luo,Tian Tian Yue,Ping Yang,Qilin Yu,Shu Zhang,Cong‐Yi Wang
摘要
Macrophages are widely distributed in various tissues and organs. They not only participate in the regulation of innate and adaptive immune response, but also play an important role in tissue homeostasis. Dysregulation of macrophage function is closely related to the initiation, development and prognosis of multiple diseases, including infection and tumorigenesis. Forkhead box transcription factor O1 (FoxO1) is an important member among the forkhead box transcription factor family. Through directly binding to the promoter regions of downstream target genes, FoxO1 is implicated in cell proliferation, apoptosis, metabolic activities and other biological processes. In this review, we summarized the regulatory role of FoxO1 in macrophage phagocytosis, migration, differentiation and inflammatory activation. We also emphasized that macrophage reciprocally modulated FoxO1 activity via a post-translational modification (PTM) dominant manner.
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