MP09-16 DOES ACTIVITY LEVEL MODULATE THE GENETIC RISK OF BPH? A COHORT STUDY FROM THE UK BIOBANK

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology, Evaluation & Medical Non-surgical Therapy (MP09)1 May 2024MP09-16 DOES ACTIVITY LEVEL MODULATE THE GENETIC RISK OF BPH? A COHORT STUDY FROM THE UK BIOBANK Alexander P. Glaser, Zhuqing Shi, Brian Helfand, and Jianfeng Xu Alexander P. GlaserAlexander P. Glaser , Zhuqing ShiZhuqing Shi , Brian HelfandBrian Helfand , and Jianfeng XuJianfeng Xu View All Author Informationhttps://doi.org/10.1097/01.JU.0001008920.55771.18.16AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: A polygenic risk score (PGS) for BPH has been developed that is associated with lower urinary tract symptoms, prostate volume, and risk of surgical intervention for BPH. Potentially modifiable risk factors such as physical activity, obesity, and sleep disturbance, as well as psychosocial factors such as anxiety/depression have also been associated lower urinary tract symptoms (LUTS), but it is unknown if these factors can modulate the inherited risk of BPH/LUTS. METHODS: Diagnosis of BPH was compared with lifestyle factors such as obesity and International Physical Activity Questionnaire (IPAQ) activity level and with diagnoses of other known risk factors including diabetes, OSA, depression, anxiety in univariate and multivariate analyses. Rate of BPH was compared between IPAQ activity group and PGS-BPH, adjusted for age and genetic background. RESULTS: 33,807 out of 228,470 male participants from the UK Biobank were diagnosed with BPH. Diagnoses of type 2 diabetes, anxiety, depression, and OSA were significantly associated with BPH (Table 1). BMI was similar in men with and without BPH (mean 27). In univariate and multivariate analysis, moderate (multivariate OR 0.95 [0.92-0.99; p=0.02] and high (OR 0.92 [0.89-0.96; p=4.65E-05]) IPAQ activity levels were associated with lower risk of BPH. Higher activity levels slightly moderated inherited genetic risk of BPH (PGS-BPH; Figure 1). CONCLUSIONS: In this large cohort study from the UK Biobank, higher levels of physical activity are associated with a decreased risk of BPH diagnosis, and higher activity levels appear to modestly influence the genetic predisposition for BPH. This study provides evidence that at least moderate physical activity should be encouraged as part of men's health. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e133 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Alexander P. Glaser More articles by this author Zhuqing Shi More articles by this author Brian Helfand More articles by this author Jianfeng Xu More articles by this author Expand All Advertisement PDF downloadLoading ...