Reversible Host–Guest Crosslinks in Supramolecular Hydrogels for On‐Demand Mechanical Stimulation of Human Mesenchymal Stem Cells (Adv. Healthcare Mater. 10/2024)

Advanced Healthcare MaterialsVolume 13, Issue 10 2470071 Back CoverFree Access Reversible Host–Guest Crosslinks in Supramolecular Hydrogels for On-Demand Mechanical Stimulation of Human Mesenchymal Stem Cells (Adv. Healthcare Mater. 10/2024) Philipp Linke, Philipp LinkeSearch for more papers by this authorNatalie Munding, Natalie MundingSearch for more papers by this authorEsther Kimmle, Esther KimmleSearch for more papers by this authorStefan Kaufmann, Stefan KaufmannSearch for more papers by this authorKentaro Hayashi, Kentaro HayashiSearch for more papers by this authorMasaki Nakahata, Masaki NakahataSearch for more papers by this authorYoshinori Takashima, Yoshinori TakashimaSearch for more papers by this authorMasaki Sano, Masaki SanoSearch for more papers by this authorMartin Bastmeyer, Martin BastmeyerSearch for more papers by this authorThomas Holstein, Thomas HolsteinSearch for more papers by this authorSascha Dietrich, Sascha DietrichSearch for more papers by this authorCarsten Müller-Tidow, Carsten Müller-TidowSearch for more papers by this authorAkira Harada, Akira HaradaSearch for more papers by this authorAnthony D. Ho, Anthony D. HoSearch for more papers by this authorMotomu Tanaka, Motomu TanakaSearch for more papers by this author Philipp Linke, Philipp LinkeSearch for more papers by this authorNatalie Munding, Natalie MundingSearch for more papers by this authorEsther Kimmle, Esther KimmleSearch for more papers by this authorStefan Kaufmann, Stefan KaufmannSearch for more papers by this authorKentaro Hayashi, Kentaro HayashiSearch for more papers by this authorMasaki Nakahata, Masaki NakahataSearch for more papers by this authorYoshinori Takashima, Yoshinori TakashimaSearch for more papers by this authorMasaki Sano, Masaki SanoSearch for more papers by this authorMartin Bastmeyer, Martin BastmeyerSearch for more papers by this authorThomas Holstein, Thomas HolsteinSearch for more papers by this authorSascha Dietrich, Sascha DietrichSearch for more papers by this authorCarsten Müller-Tidow, Carsten Müller-TidowSearch for more papers by this authorAkira Harada, Akira HaradaSearch for more papers by this authorAnthony D. Ho, Anthony D. HoSearch for more papers by this authorMotomu Tanaka, Motomu TanakaSearch for more papers by this author First published: 17 April 2024 https://doi.org/10.1002/adhm.202470071AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Supramolecular Hydrogels In article 2302607, Motomu Tanaka and co-workers show that reversible host-guest crosslinks in supramolecular hydrogels enable on-demand mechanical stimulation of human mesenchymal stem cells. A subtle change in substrate stiffness across the critical threshold turns on and off cell traction force and YAP/TAZ signaling, followed by shape adaptation. A frequent mechanical stress beyond the critical frequency suppresses the stem cell proliferation with no loss of multipotency. Volume13, Issue10April 17, 20242470071 RelatedInformation