去唾液酸糖蛋白受体
结合
化学
配体(生物化学)
半乳糖胺
阿托伐他汀
立体化学
水解
受体
生物化学
体外
药理学
半乳糖
生物
肝细胞
数学分析
数学
作者
Svetlana Yu. Maklakova,Maria P. Mazhuga,Anton V. Lopukhov,Karina R. Gibadullina,Natalia L. Klyachko,Alexander G. Majouga,Елена К. Белоглазкина
出处
期刊:Журнал органической химии
[Akademizdatcenter Nauka]
日期:2023-02-15
卷期号:59 (2): 217-227
标识
DOI:10.31857/s0514749223020076
摘要
The novel atorvastatin conjugate was synthesized in a multi-step procedure using branched N -acetylgalactosamine ligand for asialoglycoprotein receptor targeting. The molar solubility of the obtained conjugate was 6.1±0.9 mM, which is almost 60 times higher than that of unmodified atorvastatin. The hydrolysis products of the conjugate demonstrated effective inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase.
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