已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Excessive Exogenous Gonadotropins and Genetic and Pregnancy Outcomes After Euploidy Embryo Transfer

胚胎移植 活产 怀孕 不育 非整倍体 妊娠率 妇科 医学 胚胎 优势比 随机对照试验 男科 产科 生物 内科学 遗传学 基因 染色体
作者
Tianxiang Ni,Wei Zhou,Yingbo Liu,Weiran Cui,Liu Yang,Juanjuan Lu,Qian Zhang,Zi‐Jiang Chen,Yan Li,Junhao Yan
出处
期刊:JAMA network open [American Medical Association]
卷期号:7 (4): e244438-e244438
标识
DOI:10.1001/jamanetworkopen.2024.4438
摘要

Importance The safety of exogenous gonadotropin treatment, based on its effect on embryos and pregnancy outcomes, remains inconclusive. Objective To evaluate the associations of different doses and durations of gonadotropins with embryonic genetic status and pregnancy outcomes after euploid embryo transfer in couples with infertility. Design, Setting, and Participants This study was a post hoc analysis of a multicenter randomized clinical trial (RCT) conducted at 14 reproductive centers throughout China from July 2017 to June 2018 that evaluated the cumulative live birth rate with or without preimplantation genetic testing for aneuploidy (PGT-A) among couples with infertility and good prognosis. The PGT-A group from the original RCT was selected for secondary analysis. Patients were divided into 4 groups according to the total dosage of exogenous gonadotropins and treatment duration: group 1 (≤1500 IU and <10 days), group 2 (≤1500 IU and ≥10 days), group 3 (>1500 IU and <10 days), and group 4 (>1 500 IU and ≥10 days). Group 1 served as the control group. Data were analyzed from June through August 2023. Interventions Blastocyst biopsy and PGT-A. Main outcomes and measures The primary outcomes were embryonic aneuploidy, embryonic mosaicism, and cumulative live birth rates after euploid embryo transfer. Results A total of 603 couples (mean [SD] age of prospective mothers, 29.13 [3.61] years) who underwent PGT-A were included, and 1809 embryos were screened using next-generation sequencing. The embryo mosaicism rate was significantly higher in groups 2 (44 of 339 embryos [13.0%]; adjusted odds ratio [aOR], 1.69 [95% CI, 1.09-2.64]), 3 (27 of 186 embryos [14.5%]; aOR, 1.98 [95% CI, 1.15-3.40]), and 4 (82 of 651 embryos [12.6%]; aOR, 1.60 [95% CI, 1.07-2.38]) than in group 1 (56 of 633 embryos [8.8%]). There were no associations between gonadotropin dosage or duration and the embryo aneuploidy rate. The cumulative live birth rate was significantly lower in groups 2 (83 of 113 couples [73.5%]; aOR, 0.49 [95% CI, 0.27-0.88]), 3 (42 of 62 couples [67.7%]; aOR, 0.41 [95% CI, 0.21-0.82]), and 4 (161 of 217 couples [74.2%]; aOR, 0.53 [95% CI, 0.31-0.89]) than in group 1 (180 of 211 couples [85.3%]). Conclusions and relevance In this study, excessive exogenous gonadotropin administration was associated with increased embryonic mosaicism and decreased cumulative live birth rate after euploid embryo transfer in couples with a good prognosis. These findings suggest that consideration should be given to minimizing exogenous gonadotropin dosage and limiting treatment duration to improve embryo outcomes and increase the live birth rate. Trial Registration ClinicalTrials.gov Identifier: NCT03118141
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
芯之痕发布了新的文献求助10
1秒前
阿鑫完成签到 ,获得积分10
2秒前
客念完成签到 ,获得积分10
4秒前
温柔豁完成签到,获得积分10
6秒前
爱上学的小金完成签到 ,获得积分10
9秒前
迷人的天抒完成签到,获得积分10
10秒前
123123完成签到 ,获得积分10
12秒前
自然秋柳完成签到 ,获得积分10
13秒前
小蘑菇应助niu采纳,获得10
16秒前
柏小霜完成签到 ,获得积分0
16秒前
17秒前
大模型应助周雨昕采纳,获得10
17秒前
酷酷问夏完成签到 ,获得积分10
17秒前
刘闹闹完成签到 ,获得积分10
18秒前
19秒前
九九完成签到 ,获得积分10
20秒前
李治稳发布了新的文献求助10
20秒前
21秒前
24秒前
24秒前
pinklay完成签到 ,获得积分10
27秒前
我爱康康文献完成签到 ,获得积分10
27秒前
28秒前
smart发布了新的文献求助10
29秒前
niu发布了新的文献求助10
30秒前
31秒前
123完成签到 ,获得积分10
31秒前
漂亮白枫发布了新的文献求助10
32秒前
tao完成签到 ,获得积分10
33秒前
36秒前
秋天完成签到,获得积分10
39秒前
科研通AI2S应助科研通管家采纳,获得10
40秒前
40秒前
在水一方应助科研通管家采纳,获得10
40秒前
40秒前
41秒前
41秒前
所所应助科研通管家采纳,获得20
41秒前
41秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976583
求助须知:如何正确求助?哪些是违规求助? 3520659
关于积分的说明 11204399
捐赠科研通 3257298
什么是DOI,文献DOI怎么找? 1798683
邀请新用户注册赠送积分活动 877842
科研通“疑难数据库(出版商)”最低求助积分说明 806595