毒力
爆发
肺
促炎细胞因子
肺炎
猪繁殖与呼吸综合征病毒
生物
病变
疾病
炎症反应
免疫学
病毒学
病毒
病理
医学
炎症
基因
内科学
生物化学
作者
Inés Ruedas‐Torres,José María Sánchez‐Carvajal,Francisco J. Salguero,F. J. Pallarés,L. Carrasco,Enric Mateu,J. Gómez-Laguna,I.M. Rodríguez-Gómez
标识
DOI:10.3389/fvets.2024.1330990
摘要
Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important infectious diseases for the pig industry worldwide. The disease was firstly reported in 1987 and became endemic in many countries. Since then, outbreaks caused by strains of high virulence have been reported several times in Asia, America and Europe. Interstitial pneumonia, microscopically characterised by thickened alveolar septa, is the hallmark lesion of PRRS. However, suppurative bronchopneumonia and proliferative and necrotising pneumonia are also observed, particularly when a virulent strain is involved. This raises the question of whether the infection by certain strains results in an overstimulation of the proinflammatory response and whether there is some degree of correlation between the strain involved and a particular pattern of lung injury. Thus, it is of interest to know how the inflammatory response is modulated in these cases due to the interplay between virus and host factors. This review provides an overview of the macroscopic, microscopic, and molecular pathology of PRRSV-1 strains in the lung, emphasising the differences between strains of different virulence.
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