自噬
生物
细胞生物学
ULK1
伴侣(临床)
肥胖
LRRK2
内分泌学
遗传学
激酶
基因
细胞凋亡
病理
蛋白激酶A
医学
突变
安普克
作者
Tian Zhang,Ke‐Gang Linghu,Jia Tan,Mingming Wang,Chen Diao,Yan Shen,Junchao Wu,Mingjun Shi,Yüxia Zhou,Lei Tang,Lirong Liu,Zheng‐Hong Qin,Bing Guo
出处
期刊:Autophagy
[Informa]
日期:2024-04-30
卷期号:: 1-21
标识
DOI:10.1080/15548627.2024.2338576
摘要
Obesity is one of the most common metabolic diseases around the world, which is distinguished by the abnormal buildup of triglycerides within adipose cells. Recent research has revealed that autophagy regulates lipid mobilization to maintain energy balance. TIGAR (Trp53 induced glycolysis regulatory phosphatase) has been identified as a glycolysis inhibitor, whether it plays a role in the metabolism of lipids is unknown. Here, we found that TIGAR transgenic (TIGAR
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