A new paradigm in biosensing: MOF-carbon dot conjugates

材料科学 光热治疗 纳米载体 表面改性 纳米复合材料 量子点 纳米技术 荧光 药物输送 X射线光电子能谱 纳米颗粒 傅里叶变换红外光谱 生物传感器 光热效应 化学工程 物理 量子力学 工程类
作者
Shivanand H. Nannuri,Abhijeet Pandey,Sanjay Kulkarni,Prashant K. Deshmukh,Sajan D. George,Srinivas Mutalik
出处
期刊:Materials today communications [Elsevier]
卷期号:35: 106340-106340 被引量:7
标识
DOI:10.1016/j.mtcomm.2023.106340
摘要

Metal-organic frameworks (MOFs) have emerged as promising nanocarriers for targeted drug delivery, owing to their unique structural properties and tunable pore sizes. Integrating carbon dots (C-dots) into MOFs will further enhance their functionality and imaging capabilities. In this study, the synthesis and characterization of C-dots loaded MOF is detailed as a novel pH and temperature-responsive nanoplatform for the imaging and therapy of neuroblastoma. The C-dots were synthesized using a modified microwave method, and their structural and optical properties were characterized using techniques such as XRD, FTIR, and XPS. The C-dots demonstrated a hexagonal graphite structure with hydroxyl and carboxyl surface functional groups. The C-dots also exhibited green emission under excitation at 405 nm with concentration-dependent emission behaviour. The pH-dependent emission studies reveal a gradual increase in fluorescence intensity from pH 3–9, followed by a rapid decrease at higher pH values. It is observed that the fluorescence intensity decreased by ∼50% upon increasing the temperature (30–65 °C) at a step of 5 °C covering the range of physiological temperature. The photothermal studies elucidated that the C-dots exhibit good photothermal conversion properties upon NIR laser irradiation that can find applications in the areas like photothermal therapy. The drug release studies confirmed the pH-responsive drug release property of the nanocomposite. Further, the surface-modified nanocomposite was efficiently uptaken by the neuroblastoma cells suggesting the possibility of targeted therapy for cancer. Overall, this study gives new insights into the synthesis, characterisation, and functionalization of C-dots loaded with ZIF-8 NPs, revealing their potential for drug delivery applications.
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