蜂鸟
生物
基因敲除
线粒体
己糖激酶
基因
糖酵解
细胞生物学
遗传学
酶
生物化学
生态学
作者
Ekaterina Osipova,Rico Barsacchi,Tom Brown,Keren R. Sadanandan,Andrea H. Gaede,Amanda Monte,Julia Jarrells,Claudia Moebius,Martin Pippel,Douglas L. Altshuler,Sylke Winkler,Marc Bickle,Maude W. Baldwin,Michael Hiller
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2023-01-12
卷期号:379 (6628): 185-190
被引量:21
标识
DOI:10.1126/science.abn7050
摘要
Hummingbirds possess distinct metabolic adaptations to fuel their energy-demanding hovering flight, but the underlying genomic changes are largely unknown. Here, we generated a chromosome-level genome assembly of the long-tailed hermit and screened for genes that have been specifically inactivated in the ancestral hummingbird lineage. We discovered that FBP2 (fructose-bisphosphatase 2), which encodes a gluconeogenic muscle enzyme, was lost during a time period when hovering flight evolved. We show that FBP2 knockdown in an avian muscle cell line up-regulates glycolysis and enhances mitochondrial respiration, coincident with an increased mitochondria number. Furthermore, genes involved in mitochondrial respiration and organization have up-regulated expression in hummingbird flight muscle. Together, these results suggest that FBP2 loss was likely a key step in the evolution of metabolic muscle adaptations required for true hovering flight.
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