Efficacy of Lianhua Qingwen for children with SARS-CoV-2 Omicron infection: A propensity score-matched retrospective cohort study

医学 内科学 回顾性队列研究 队列 危险系数 倾向得分匹配 严重急性呼吸综合征冠状病毒2型(SARS-CoV-2) 胃肠病学 2019年冠状病毒病(COVID-19) 疾病 置信区间 传染病(医学专业)
作者
Xiangru Xu,Hongze Wu,Guoqiang Jin,Jihan Huang,Jinhua Li,Jing Zhou,Min Cao,Ding Sun,Wen Zhang,Wei Peng,Yuting Pu,Caiyu Chen,Yuting Sun,Hongqiang Yang,Shuang Zhou,Bangjiang Fang
出处
期刊:Phytomedicine [Elsevier]
卷期号:111: 154665-154665 被引量:8
标识
DOI:10.1016/j.phymed.2023.154665
摘要

Lianhua Qingwen Granules or Capsules (LHQW) has accumulated much research evidence in the fight against the coronavirus disease 2019 (COVID-19) epidemic. However, there are still few data on its efficacy and safety in children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To evaluate the efficacy and safety of LHQW in children with SARS-CoV-2 Omicron infection. We conducted a single-center, propensity-score matched retrospective cohort study of children with SARS-CoV-2 Omicron infection in Shanghai New International Expo Center mobile cabin hospital between April 1st and June 1st, 2022. Eligible patients received either LHQW granules/capsules plus supportive care (LHQW group) or supportive care alone (control group). The primary outcome was the negative conversion time of nucleic acid. Secondary outcomes included the negative conversion rate of nucleic acid, the length of hospital stay, clinical disease progression, and cycle threshold [Ct] values for SARS-CoV-2 open reading frame [ORF1ab] or nucleocapsid [N] genes. Overall, 2808 patients were enrolled, and 346 patients in each group were included in the analysis. Among the propensity-score matched groups, LHQW treatment was associated with an accelerated negative conversion time of nucleic acid (median: 5 d vs. 6 d, Hazard ratio: 1.25, 95% CI: 1.08 – 1.46, Log-rank p < 0.001), a higher negative conversion rate of nucleic acid (Day 2 – 6: 2.9% vs. 0.6%, p = 0.036; 29.8% vs. 5.5%, p < 0.001; 42.5% vs. 24.3%, p < 0.001; 51.4% vs. 31.5%, p < 0.001; 63.3% vs. 55.2%, p = 0.030), shorter hospital stay (median: 10 d vs. 11 d, Hazard ratio: 1.50, 95% CI: 1.29 – 1.74, Log-rank p < 0.001), and lower rates of asymptomatic infection progressing to mild (37.9% vs. 46.5%, p = 0.021). Our study suggested that LHQW treatment was associated with faster clinical recovery in children with SARS-CoV-2 Omicron infection.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
俊秀的安阳完成签到,获得积分10
1秒前
hahahahaha完成签到,获得积分10
1秒前
不配.应助keke采纳,获得10
1秒前
科研通AI2S应助淡漠采纳,获得10
2秒前
2秒前
4秒前
张雯雯完成签到,获得积分10
7秒前
romme发布了新的文献求助10
7秒前
8秒前
开心发布了新的文献求助10
8秒前
蒲柳完成签到,获得积分10
10秒前
10秒前
10秒前
alexyusheng完成签到,获得积分10
13秒前
sxw发布了新的文献求助10
13秒前
13秒前
小小瑾完成签到,获得积分10
15秒前
玖梦发布了新的文献求助10
15秒前
大个应助正直的妍采纳,获得10
15秒前
16秒前
alexyusheng发布了新的文献求助10
17秒前
18秒前
Janus完成签到,获得积分10
18秒前
20秒前
21秒前
Jasper应助玖梦采纳,获得10
21秒前
夜绿完成签到 ,获得积分10
21秒前
ZZ完成签到,获得积分10
22秒前
席半完成签到,获得积分10
23秒前
大个应助Janus采纳,获得10
23秒前
天天快乐应助科研通管家采纳,获得10
24秒前
爆米花应助科研通管家采纳,获得10
24秒前
烟花应助科研通管家采纳,获得10
24秒前
SciGPT应助科研通管家采纳,获得10
24秒前
科研通AI2S应助科研通管家采纳,获得10
24秒前
24秒前
24秒前
24秒前
英姑应助科研通管家采纳,获得10
24秒前
高分求助中
Sustainability in Tides Chemistry 2800
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Very-high-order BVD Schemes Using β-variable THINC Method 568
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3138641
求助须知:如何正确求助?哪些是违规求助? 2789658
关于积分的说明 7791857
捐赠科研通 2445999
什么是DOI,文献DOI怎么找? 1300813
科研通“疑难数据库(出版商)”最低求助积分说明 626058
版权声明 601079