Interferon-gamma (IFN-γ): Reviewing its mechanisms and signaling pathways on the regulation of endothelial barrier function

细胞生物学 信号转导 势垒函数 细胞因子 功能(生物学) 生物 MAPK/ERK通路 干扰素 免疫系统 干扰素γ 免疫学
作者
Chin Theng Ng,Lai Yen Fong,Muhammad Nazrul Hakim Abdullah
出处
期刊:Cytokine [Elsevier BV]
卷期号:166: 156208-156208 被引量:29
标识
DOI:10.1016/j.cyto.2023.156208
摘要

Interferon-gamma (IFN-γ) is a pleiotropic cytokine that plays a critical role in mediating an array of immune responses including promotes antiviral activity, facilitates macrophage activation, controls Th1/Th2 balance, and regulates cellular apoptosis and proliferation. A few articles have previously reviewed the effects of IFN-γ in the regulation of barrier permeability, but none of these articles focuses on barrier function of endothelial cells. This review aims to discuss the regulatory mechanisms of IFN-γ on endothelial barrier function and its underlying signaling pathways. Articles were retrieved from electronic databases such as PubMed and Google Scholar using keywords “Interferon-gamma”, “endothelial cells”, “barrier function”, and “signaling pathway”. The articles published between 2000 and 2022 that are related to the aforementioned topics were selected. A few journals published beyond this period were also included due to limited information available. The results showed that IFN-γ modulates endothelial barrier function, mainly involves small GTPases, STAT1-dependent pathway, p38 MAPK and nitric oxide. In conclusion, more in depth cellular and molecular studies are needed to elucidate the pathways of IFN-γ in the regulation of endothelial barrier function.
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