Ortho Heterobimetallic Arylene Complex: A New Platform for Regioselective Difunctionalization

Abstract Regioselective ortho difunctionalization of arenes is highly desirable yet challenging in organic synthesis. Here, we briefly discuss various methods for ortho difunctionalization of arenes and highlight a novel ortho-heterobimetallic arylene complex enabled by heterobimetallic synergism, which shows great potential in regioselective ortho difunctionalizations. 1 Introduction 2 Distinct Reactivity of C–Fe and C–Ti Bonds 3 E/E′ ODFs by Fe/Ti-Heterobimetallic Intermediate 4 Nu/E ODFs by Fe/Ti -Heterobimetallic Intermediate 5 Summary and Outlook