Positive fecal immunochemical test but negative colonoscopy: what’s next?

Screening for colorectal cancer (CRC) using the fecal immunochemical test (FIT) has been rapidly implemented worldwide. Alongside primary colonoscopy, it is a first-tier recommended screening test. FIT testing offers several advantages, including noninvasiveness, high acceptance among the target population, and cost-effectiveness [1] [2] [3]. However, it is not without challenges, particularly concerning the management of individuals with a negative colonoscopy following a positive FIT result.