Chemical constituents of the marine-derived fungus Acremonium sp. AN-13

AbstractTwo new compounds named 3(S)-hydroxy-1-(2,4,5-trihydroxy-3,6- dimethylphenyl)-hex-4E-en-1-one (1) and acremonilactone (2), together with nine known compounds (3–11), were isolated from the fermentation broth of Acremonium sp. associated with marine sediments collected from South China Sea. NMR and HRESIMS spectroscopic analysis elucidated the structure of two new compounds. Compound 2 had characteristic rotary gate shape skeleton with a six-membered lactone. Compounds 1 and 9 showed DPPH radical scavenging activity with inhibition rates of 96.50 and 85.95% at the concentration of 0.5 mg/ml, respectively. Moreover, compounds 4, 6 and 11 showed definite antibacterial activity against Staphylococcus aureus ATCC 6538.Keywords: Marine sediment-derived fungiAcremonium sp.secondary metabolitesantioxidant and antibacterial activities Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThis work was financially supported by Natural Science Foundation of Hainan Province [420QN340], Financial Fund of the Ministry of Agriculture and Rural Affairs, China [NFZX2021], the earmarked fund for China Agriculture Research System [CARS-21].