伤口愈合
透明质酸
生物相容性
自愈水凝胶
壳聚糖
席夫碱
细胞外基质
复合数
化学
再生(生物学)
高分子化学
材料科学
化学工程
生物医学工程
有机化学
生物化学
复合材料
外科
细胞生物学
医学
工程类
生物
解剖
作者
Jiankang Li,Jingjing Su,Jiaheng Liang,Kun Zhang,Mengbo Xie,Bingjie Cai,Jingan Li
标识
DOI:10.1016/j.ijbiomac.2023.128284
摘要
The healing of full-thickness skin defect has been a clinical challenge. Hydrogels with multiple functions inspired by extracellular matrix are expected to be used as wound dressing. In this paper, dopamine-grafted oxidized hyaluronic acid was blended with quaternary ammonium chitosan to form a composite functionalized hydrogel by enzyme-catalyzed cross-linking and Schiff base reaction. The hydrogel has convenient preparation, good biocompatibility, antibacterial and antioxidant, high adhesion and self-healing properties. The results in vivo show that the hydrogel can effectively close the wound and accelerate the speed of wound healing by up-regulating the expression of angiogenic protein and promoting the distribution of collagen deposition more uniform and regular. It is expected that this composite functionalized hydrogel dressing has great potential in wound regeneration.
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