透明质酸
流变学
填料(材料)
真皮成纤维细胞
材料科学
粘度
生物医学工程
表征(材料科学)
化学工程
复合材料
体外
化学
纳米技术
成纤维细胞
生物化学
医学
工程类
解剖
作者
Stefano Pluda,Cecilia Salvagnini,A. Fontana,Anna Marchetti,Alba Di Lucia,Devis Galesso,Cristian Guarise
出处
期刊:Gels
[MDPI AG]
日期:2023-09-09
卷期号:9 (9): 733-733
被引量:11
摘要
Despite process similarities, distinctive manufacturing technologies offer hyaluronic acid dermal fillers with different in vitro physicochemical and rheological properties due to peculiar crosslinked hydrogel networks. A better understanding of dermal filler properties could provide specific clinical indications and expectations with more accurate performance correlations. In this study, with an emphasis on the degree of modification, hyaluronic acid concentration and molecular weight, these process parameters were able to modulate dermal filler properties, especially rheology. Moreover, an extensive characterization of commercial hyaluronic acid injectables of the Hyal System line was described to present product properties and help to elucidate related clinical effects. Standardized methodologies were applied to correlate in vitro parameters with feasible clinical indications. In view of an optimized dermal filler design, the results of the extrudability measurements allowed the quantification of the effect of hydrogel composition, rheological properties and needle size on injectability. Composition, dynamic viscosity and needle size showed an impactful influence on hydrogel extrudability. Finally, the positive influence of 200 KDa hyaluronic acid in comparison to fragments of ether-crosslinked hyaluronic acid on fibroblast recognition were shown with a migration assay.
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