已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Systemic Therapy for Tumor Control in Metastatic Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline

医学 舒尼替尼 依维莫司 神经内分泌肿瘤 放射性核素治疗 肿瘤科 内科学 全身疗法 化疗 实体瘤疗效评价标准 靶向治疗 癌症 进行性疾病 乳腺癌
作者
Jaydira Del Rivero,Kimberly Perez,Erin B. Kennedy,Erik Mittra,Namrata Vijayvergia,Junaid Arshad,Sandip Basu,Aman Chauhan,Arvind Dasari,Andrew M. Bellizzi,Michal G. Rose,Erin Grady,James R. Howe,Jana Ivanidze,Mark A. Lewis,Josh Mailman,Nitya Raj,Heloisa P. Soares,Michael C. Soulen,Sarah B. White,Jennifer A. Chan,Pamela L. Kunz,Simron Singh,Þorvarður R. Hálfdánarson,Jonathan Strosberg,Emily K. Bergsland
出处
期刊:Journal of Clinical Oncology [American Society of Clinical Oncology]
卷期号:41 (32): 5049-5067 被引量:12
标识
DOI:10.1200/jco.23.01529
摘要

PURPOSE To develop recommendations for systemic therapy for well-differentiated grade 1 (G1) to grade 3 (G3) metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs). METHODS ASCO convened an Expert Panel to conduct a systematic review of relevant studies and develop recommendations for clinical practice. RESULTS Eight randomized controlled trials met the inclusion criteria for the systematic review. RECOMMENDATIONS Somatostatin analogs (SSAs) are recommended as first-line systemic therapy for most patients with G1-grade 2 (G2) metastatic well-differentiated GI-NETs. Observation is an option for patients with low-volume or slow-growing disease without symptoms. After progression on SSAs, peptide receptor radionuclide therapy (PRRT) is recommended as systematic therapy for patients with somatostatin receptor (SSTR)–positive tumors. Everolimus is an alternative second-line therapy, particularly in nonfunctioning NETs and patients with SSTR-negative tumors. SSAs are standard first-line therapy for SSTR-positive pancreatic (pan)NETs. Rarely, observation may be appropriate for asymptomatic patients until progression. Second-line systemic options for panNETs include PRRT (for SSTR-positive tumors), cytotoxic chemotherapy, everolimus, or sunitinib. For SSTR-negative tumors, first-line therapy options are chemotherapy, everolimus, or sunitinib. There are insufficient data to recommend particular sequencing of therapies. Patients with G1-G2 high-volume disease, relatively high Ki-67 index, and/or symptoms related to tumor growth may benefit from early cytotoxic chemotherapy. For G3 GEP-NETs, systemic options for G1-G2 may be considered, although cytotoxic chemotherapy is likely the most effective option for patients with tumor-related symptoms, and SSAs are relatively ineffective. Qualifying statements are provided to assist with treatment choice. Multidisciplinary team management is recommended, along with shared decision making with patients, incorporating their values and preferences, potential benefits and harms, and other characteristics and circumstances, such as comorbidities, performance status, geographic location, and access to care. Additional information is available at www.asco.org/gastrointestinal-cancer-guidelines .
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小芳应助Supermao采纳,获得20
刚刚
2秒前
X7完成签到,获得积分10
2秒前
失眠无声发布了新的文献求助10
2秒前
artemis发布了新的文献求助10
3秒前
酷波er应助专注煜祺采纳,获得10
3秒前
笑点低的阑悦完成签到 ,获得积分10
4秒前
yxl01yxl完成签到,获得积分10
4秒前
NexusExplorer应助薛华倩采纳,获得10
7秒前
zxf驳回了情怀应助
8秒前
小蘑菇应助无语的乾采纳,获得10
8秒前
ran完成签到,获得积分10
9秒前
打打应助钪锵玫瑰采纳,获得10
13秒前
laz完成签到,获得积分10
13秒前
领导范儿应助蓝莓小蛋糕采纳,获得10
14秒前
研友_VZG7GZ应助靳顺康采纳,获得10
15秒前
大卫发布了新的文献求助10
16秒前
17秒前
ykgoose完成签到,获得积分10
17秒前
18秒前
华仔应助冷静新烟采纳,获得10
18秒前
19秒前
19秒前
21秒前
Jackylee完成签到,获得积分10
24秒前
小马甲应助予陆与你采纳,获得10
24秒前
Dragonfln完成签到,获得积分10
24秒前
薛华倩发布了新的文献求助10
25秒前
25秒前
Vivian完成签到,获得积分20
25秒前
大方从彤完成签到,获得积分10
26秒前
无语的乾发布了新的文献求助10
26秒前
26秒前
甜蜜花完成签到,获得积分10
26秒前
sanmao发布了新的文献求助30
26秒前
所所应助碗碗采纳,获得10
27秒前
29秒前
30秒前
tsuki完成签到 ,获得积分10
31秒前
靳顺康发布了新的文献求助10
32秒前
高分求助中
Licensing Deals in Pharmaceuticals 2019-2024 3000
Effect of reactor temperature on FCC yield 2000
Very-high-order BVD Schemes Using β-variable THINC Method 1020
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Mission to Mao: Us Intelligence and the Chinese Communists in World War II 600
The Conscience of the Party: Hu Yaobang, China’s Communist Reformer 600
MATLAB在传热学例题中的应用 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3302955
求助须知:如何正确求助?哪些是违规求助? 2937218
关于积分的说明 8481279
捐赠科研通 2611147
什么是DOI,文献DOI怎么找? 1425657
科研通“疑难数据库(出版商)”最低求助积分说明 662425
邀请新用户注册赠送积分活动 646861