脚手架
生物相容性
材料科学
静电纺丝
极限抗拉强度
磷灰石
生物医学工程
同种类的
再生(生物学)
骨组织
骨愈合
生物物理学
化学
复合材料
解剖
细胞生物学
矿物学
聚合物
医学
物理
生物
冶金
热力学
作者
Zhengwei Li,Tianming Du,Chongjian Gao,Lan Tang,Kinon Chen,Juan Liu,Jun Yang,Xiaoli Zhao,Xufeng Niu,Changshun Ruan
出处
期刊:Biofabrication
[IOP Publishing]
日期:2022-09-14
卷期号:14 (4): 045016-045016
被引量:14
标识
DOI:10.1088/1758-5090/ac8dc7
摘要
For guided bone regeneration (GBR) in clinical orthopedics, the importance of a suitable scaffold which can provide the space needed for bone regeneration and simultaneously promotes the new bone formation cannot be overemphasized. Due to its excellent biocompatibility, mechanical strength, and similarity in structure and composition to natural bone, the mineralized collagen-based scaffolds have been increasingly considered as promising GBR scaffolds. Herein, we propose a novel method to fabricate anin-situmineralized homogeneous collagen-based scaffold (IMHCS) with excellent osteogenic capability for GBR by electrospinning the collagen solution in combination with essential mineral ions. The IMHCS exhibited homogeneous distribution of apatite crystals in electrospun fibers, which helped to achieve a significantly higher tensile strength than the pure collagen scaffold (CS) and the scaffold with directly added nano-hydroxyapatite particles (HAS). Furthermore, the IMHCS had significantly better cell compatibility, cell migration ratio, and osteogenic differentiation property than the HAS and CS. Therefore, the IMHCS not only retains traditional function of inhibiting fibroblast invasion, but also possesses excellent osteogenic differentiation property, indicating a robust alternative for GBR applications.
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