DNA去甲基化
染色质
生物
表观遗传学
表观遗传学
抄写(语言学)
遗传学
细胞生物学
DNA
核糖核酸
DNA甲基化
基因
基因表达
语言学
哲学
作者
Shuang Deng,Jialiang Zhang,Jiachun Su,Zhixiang Zuo,Lingxing Zeng,Kaijing Liu,Yanfen Zheng,Xudong Huang,Ruihong Bai,Lisha Zhuang,Ying Ye,Mei Li,Ling Pan,Junge Deng,Guandi Wu,Rui Li,Shaoping Zhang,Chen Wu,Dongxin Lin,Jianjun Chen,Jian Zheng
出处
期刊:Nature Genetics
[Springer Nature]
日期:2022-09-01
卷期号:54 (9): 1427-1437
被引量:67
标识
DOI:10.1038/s41588-022-01173-1
摘要
Transcriptional regulation, which integrates chromatin accessibility, transcription factors and epigenetic modifications, is crucial for establishing and maintaining cell identity. The interplay between different epigenetic modifications and its contribution to transcriptional regulation remains elusive. Here, we show that METTL3-mediated RNA N6-methyladenosine (m6A) formation leads to DNA demethylation in nearby genomic loci in normal and cancer cells, which is mediated by the interaction between m6A reader FXR1 and DNA 5-methylcytosine dioxygenase TET1. Upon recognizing RNA m6A, FXR1 recruits TET1 to genomic loci to demethylate DNA, leading to reprogrammed chromatin accessibility and gene transcription. Therefore, we have characterized a regulatory mechanism of chromatin accessibility and gene transcription mediated by RNA m6A formation coupled with DNA demethylation, highlighting the importance of the crosstalk between RNA m6A and DNA modification in physiologic and pathogenic process.
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