Bioelectric fields coordinate wound contraction and re-epithelialization process to accelerate wound healing via promoting myofibroblast transformation

伤口愈合 肌成纤维细胞 哈卡特 细胞生物学 收缩(语法) 成纤维细胞 体外 化学 细胞迁移 体内 药理学 医学 生物 免疫学 病理 生物化学 纤维化 内科学 遗传学
作者
Jinrui Yang,Xiaoqiang Liu,Wenping Wang,Ying Chen,Jie Liu,Ze Zhang,Chao Wu,Xupin Jiang,Yi Liang,Jiaping Zhang
出处
期刊:Bioelectrochemistry [Elsevier]
卷期号:148: 108247-108247 被引量:15
标识
DOI:10.1016/j.bioelechem.2022.108247
摘要

Electric fields (EFs) are thought to play a decisive role in wound healing. However, most studies focused on the effects of EF on single species of cells in vitro. Here, we aimed to investigate the coordination function of EFs on wound healing. Using a bamamini pig whole-layer wound model, we further evaluated the potential of EFs as a treatment modality by applying continuous and stable EF to the wound, and we found that EF promoted wound contraction and re-epithelialization in vivo, which accelerated wound healing. In vitro, we found that EFs significantly promoted the collective migration of HaCaT cells, guided HSF cells rearrangement, and promoted collagen secretion and myofibroblast transformation, and the electrotaxis of HaCaT cells was significantly enhanced on the collagen substrate and F-actin polarization at the leading edge of the cells was more pronounced. Overall, we determined that EF promotes wound contraction by promoting myofibrillar transformation, while accelerating the formation of collagen substrates, and the substrates could provide a good basis for electric field-guided re-epithelialization. EF may promote wound healing in multiple dimensions interaction and coordinate the whole process of wound healing. These findings provide support for the continued development of EF for wound treatment applications.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
yehaidadao完成签到,获得积分10
刚刚
刚刚
1秒前
CodeCraft应助mesome采纳,获得10
2秒前
2秒前
Kaylee应助科研通管家采纳,获得20
4秒前
情怀应助科研通管家采纳,获得10
4秒前
SciGPT应助科研通管家采纳,获得10
4秒前
传奇3应助科研通管家采纳,获得10
4秒前
orixero应助科研通管家采纳,获得10
4秒前
SciGPT应助科研通管家采纳,获得10
4秒前
Jasper应助科研通管家采纳,获得10
4秒前
研友_VZG7GZ应助科研通管家采纳,获得10
4秒前
4秒前
852应助科研通管家采纳,获得10
4秒前
Lucas应助科研通管家采纳,获得50
4秒前
搜集达人应助科研通管家采纳,获得10
5秒前
CodeCraft应助科研通管家采纳,获得10
5秒前
香蕉觅云应助科研通管家采纳,获得10
5秒前
Hello应助科研通管家采纳,获得30
5秒前
5秒前
隐形曼青应助科研通管家采纳,获得10
5秒前
qin希望应助科研通管家采纳,获得10
5秒前
5秒前
5秒前
5秒前
凯撒发布了新的文献求助10
7秒前
愤怒的蛋挞完成签到,获得积分10
8秒前
9秒前
贪玩小蘑菇完成签到 ,获得积分10
13秒前
可爱倪倪发布了新的文献求助10
14秒前
善学以致用应助fang采纳,获得10
14秒前
17秒前
酷波er应助开朗的不正采纳,获得10
18秒前
浩浩桑完成签到 ,获得积分10
19秒前
20秒前
zanzan完成签到,获得积分10
20秒前
Ava应助苏苏采纳,获得10
21秒前
22秒前
Cheetahhh完成签到,获得积分10
23秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3188568
求助须知:如何正确求助?哪些是违规求助? 2838018
关于积分的说明 8018336
捐赠科研通 2500742
什么是DOI,文献DOI怎么找? 1335163
科研通“疑难数据库(出版商)”最低求助积分说明 637477
邀请新用户注册赠送积分活动 605506