Development of κ-carrageenan-PEG/lecithin bioactive hydrogel membranes for antibacterial adhesion and painless detachment

PEG比率 聚乙二醇 差示扫描量热法 粘附 明胶 化学工程 自愈水凝胶 傅里叶变换红外光谱 卡拉胶 肿胀 的 材料科学 扫描电子显微镜 卵磷脂 化学 高分子化学 色谱法 复合材料 有机化学 生物化学 物理 财务 工程类 经济 热力学
作者
Pratibha Singh,Chetna Verma,Amlan Gupta,Samrat Mukhopadhyay,Bhuvanesh Gupta
出处
期刊:International Journal of Biological Macromolecules [Elsevier BV]
卷期号:247: 125789-125789 被引量:3
标识
DOI:10.1016/j.ijbiomac.2023.125789
摘要

The issue of wound dressing adherence poses a substantial challenge in the field of wound care, with implications both clinically and economically. Overcoming this challenge requires the development of a hydrogel dressing that enables painless removal without causing any secondary damage. However, addressing this issue still remains a significant challenge that requires attention and further exploration. The present study is focused on the synthesis of hydrogel membranes based on κ-carrageenan (CG), polyethylene glycol (PEG), and soy lecithin (LC), which can provide superior antioxidant and antibacterial attachment properties with a tissue anti adhesion activity for allowing an easy removability without causing secondary damage. The (CG-PEG)/LC mass ratio was varied to fabricate hydrogel membranes via a facile approach of physical blending and solution casting. The physicochemical properties of (CG-PEG)/LC hydrogel membranes were studied by scanning electron microscopy (SEM), Fourier transforms infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), and mechanical analyses. The membranes showed significantly enhanced mechanical properties with excellent flexibility and had high swelling capacity (˃1000 %), which would provide a moist condition for wound healing. The membranes also exhibited excellent free radical scavenging ability (>60 %). In addition, the (CG-PEG)/LC hydrogel membranes showed reduced peel strength 26.5 N/m as a result of weakening the hydrogel-gelatin interface during an in vitro gelatin peeling test. Moreover, the membrane showed superior antibacterial adhesion activity (>90 %) against both S. aureus and E. coli due to the presence of both PEG and LC. The results also suggested that the hydrogel membranes exhibit NIH3T3 cell antiadhesion property, making them promising material for easy detachment from the healed tissue without causing secondary damage. Thus, this novel combination of (CG-PEG)/LC hydrogel membranes have immense application potential as a biomaterial in the healthcare sector.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研韭菜发布了新的文献求助10
1秒前
饱满元灵完成签到 ,获得积分10
2秒前
dxdy完成签到,获得积分10
2秒前
我是老大应助蝉鸣采纳,获得10
2秒前
LIU完成签到,获得积分10
2秒前
是龙龙呀完成签到,获得积分10
3秒前
小马甲应助微微采纳,获得10
3秒前
3秒前
4秒前
4秒前
华仔应助Yimi采纳,获得10
4秒前
淡然的凝荷关注了科研通微信公众号
4秒前
zb完成签到,获得积分10
5秒前
下雨天完成签到,获得积分10
5秒前
ai六月份完成签到,获得积分10
5秒前
吴邪发布了新的文献求助10
5秒前
科研通AI2S应助冷静的奇迹采纳,获得10
5秒前
Song发布了新的文献求助10
6秒前
123完成签到,获得积分10
6秒前
7秒前
jinxixi完成签到,获得积分10
7秒前
terrell完成签到,获得积分10
7秒前
Orange应助自信以冬采纳,获得10
7秒前
1234567完成签到,获得积分10
8秒前
杨仔完成签到,获得积分10
8秒前
邢遇完成签到,获得积分10
8秒前
zb发布了新的文献求助10
9秒前
9秒前
123完成签到,获得积分10
10秒前
搬运工完成签到,获得积分10
10秒前
ALONE完成签到,获得积分10
10秒前
11秒前
西部牛仔完成签到,获得积分20
11秒前
12秒前
porcelain完成签到,获得积分10
13秒前
13秒前
13秒前
FashionBoy应助freedom采纳,获得10
13秒前
许愿完成签到 ,获得积分10
14秒前
怡然的向南完成签到,获得积分10
14秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968844
求助须知:如何正确求助?哪些是违规求助? 3513769
关于积分的说明 11169920
捐赠科研通 3249095
什么是DOI,文献DOI怎么找? 1794630
邀请新用户注册赠送积分活动 875278
科研通“疑难数据库(出版商)”最低求助积分说明 804755