Development of κ-carrageenan-PEG/lecithin bioactive hydrogel membranes for antibacterial adhesion and painless detachment

PEG比率 聚乙二醇 差示扫描量热法 粘附 明胶 化学工程 自愈水凝胶 傅里叶变换红外光谱 卡拉胶 肿胀 的 材料科学 扫描电子显微镜 卵磷脂 化学 高分子化学 色谱法 复合材料 有机化学 生物化学 物理 财务 工程类 经济 热力学
作者
Pratibha Singh,Chetna Verma,Amlan Gupta,Samrat Mukhopadhyay,Bhuvanesh Gupta
出处
期刊:International Journal of Biological Macromolecules [Elsevier BV]
卷期号:247: 125789-125789 被引量:3
标识
DOI:10.1016/j.ijbiomac.2023.125789
摘要

The issue of wound dressing adherence poses a substantial challenge in the field of wound care, with implications both clinically and economically. Overcoming this challenge requires the development of a hydrogel dressing that enables painless removal without causing any secondary damage. However, addressing this issue still remains a significant challenge that requires attention and further exploration. The present study is focused on the synthesis of hydrogel membranes based on κ-carrageenan (CG), polyethylene glycol (PEG), and soy lecithin (LC), which can provide superior antioxidant and antibacterial attachment properties with a tissue anti adhesion activity for allowing an easy removability without causing secondary damage. The (CG-PEG)/LC mass ratio was varied to fabricate hydrogel membranes via a facile approach of physical blending and solution casting. The physicochemical properties of (CG-PEG)/LC hydrogel membranes were studied by scanning electron microscopy (SEM), Fourier transforms infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), and mechanical analyses. The membranes showed significantly enhanced mechanical properties with excellent flexibility and had high swelling capacity (˃1000 %), which would provide a moist condition for wound healing. The membranes also exhibited excellent free radical scavenging ability (>60 %). In addition, the (CG-PEG)/LC hydrogel membranes showed reduced peel strength 26.5 N/m as a result of weakening the hydrogel-gelatin interface during an in vitro gelatin peeling test. Moreover, the membrane showed superior antibacterial adhesion activity (>90 %) against both S. aureus and E. coli due to the presence of both PEG and LC. The results also suggested that the hydrogel membranes exhibit NIH3T3 cell antiadhesion property, making them promising material for easy detachment from the healed tissue without causing secondary damage. Thus, this novel combination of (CG-PEG)/LC hydrogel membranes have immense application potential as a biomaterial in the healthcare sector.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
luckweb完成签到,获得积分10
3秒前
猫的毛完成签到 ,获得积分10
4秒前
nicky完成签到 ,获得积分10
5秒前
麦子完成签到 ,获得积分10
6秒前
6秒前
Wilson完成签到 ,获得积分10
7秒前
luckweb发布了新的文献求助10
7秒前
7秒前
11秒前
14秒前
传奇3应助wujiwuhui采纳,获得10
16秒前
开心寄松完成签到,获得积分10
18秒前
北宫完成签到 ,获得积分10
18秒前
wansida完成签到,获得积分10
22秒前
QXS完成签到 ,获得积分10
22秒前
23秒前
菠萝完成签到 ,获得积分10
23秒前
领导范儿应助Villanellel采纳,获得10
27秒前
wintersss完成签到,获得积分10
27秒前
尹尹发布了新的文献求助10
28秒前
量子星尘发布了新的文献求助10
30秒前
zzzzzz完成签到 ,获得积分10
34秒前
坦率的枕头完成签到,获得积分10
34秒前
XS_QI完成签到 ,获得积分10
34秒前
与共发布了新的文献求助10
37秒前
苑阿宇完成签到 ,获得积分10
37秒前
yck1027完成签到,获得积分10
38秒前
fatcat完成签到,获得积分10
38秒前
斯文败类应助Camus采纳,获得10
39秒前
41秒前
Tammy完成签到 ,获得积分10
41秒前
Herisland完成签到 ,获得积分10
43秒前
lulalula完成签到,获得积分10
44秒前
NEO完成签到 ,获得积分10
46秒前
zcydbttj2011完成签到 ,获得积分10
48秒前
温暖的小鸭子完成签到,获得积分10
50秒前
54秒前
王泽厚发布了新的文献求助20
55秒前
雪花发布了新的文献求助10
57秒前
周全完成签到 ,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038066
求助须知:如何正确求助?哪些是违规求助? 3575779
关于积分的说明 11373801
捐赠科研通 3305584
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022