A Cyclical Magneto-Responsive Massage Dressing for Wound Healing

Mechanically active wound dressing has received wide attention as its promising function in accelerating wound healing by actively contraction. However, few studies have explored the effect of sustained dynamic contraction on wound closure. The duration and magnitude of external force/deformation required to induce wound shrinking were still unknown. Herein, a magneto-responsive massage membrane (MMM) to actively and cyclically contract the wound was developed, which could be periodically activated to deform by a dynamic magnetic field device. In vitro wound model, the correlation between stimulus duration and cellular mechanotransduction signal pathway was determined, and the effects of stimulus amplitude and frequency on cell differentiation were explored. The results showed that 30min, 6% and 1Hz massage activated the mechanical signal channel and aggrandized the expression of wound healing-related proteins. The animal experiments further verified that dynamic massage can speed up the healing process by improving re-epithelization and mediating dermal contraction.