Thermosensitive hydrogel-mediated sphere/fiber multi-dimensional composite nanotube with controlled release of NGF for improved spinal cord injury repair

脊髓损伤 再生(生物学) 脊髓 材料科学 纳米管 生物医学工程 自愈水凝胶 组织工程 纳米技术 医学 神经科学 细胞生物学 碳纳米管 生物 高分子化学
作者
Xiaoli Song,Mengran Li,Xiaojun Feng,Junliang Liu,Hangyu Ji,Jun Gu
出处
期刊:European Polymer Journal [Elsevier BV]
卷期号:181: 111673-111673 被引量:6
标识
DOI:10.1016/j.eurpolymj.2022.111673
摘要

Spinal cord injury is a serious disabling disease that not only causes physical defects, but also causes psychological problems for patients. In the current study, a novel multi-dimensional functional composite nanotube was prepared by simultaneously riveting nerve growth factor (NGF)-loaded PLGA microspheres and tissue-engineered cells (BMSCs) into the PLA fiber nanotube by a designed thermosensitive hydrogel to improve spinal cord injury (SCI) repair. The PLGA microspheres allow the protection and long-term controlled release of NGF to guarantee enough time and drug concentration to promote the growth and differentiation of cells into axons and promote axonal regeneration. Thermosensitive hydrogels are served not only to provide a tunable physiologically simulated microenvironment, but also as scaffolds to provide a suitable matrix for cells and drugs, and PLA nanotube ensures the seal of the released NGF in the nanotube to improve its drug bioavailability, as well as the supporting and guiding of the nerve growth. The physicochemical properties of the composite nanotube are investigated and the repair efficacy is evaluated according to the functional recovery, histological, immunohistochemistry, immunofluorescence examinations as well as the westernblot analysis. The administration of the composite nanotube in the SCI rat models obviously improves the regeneration of the neuron, axon, myelin sheath, neural stem cell and nissnei body but decreases the astrocytes formation, as well as enhances the integrity of the spinal cord tissue and the recovery of locomotor functions. This present work provides a future perspective for NGF application and a potential strategy for SCI repair.
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