A neuropsychological profile and its correlation with neuroimaging markers in patients with subcortical ischaemic vascular dementia

神经心理学 痴呆 认知 血管性痴呆 神经心理评估 神经影像学 听力学 心理学 情景记忆 记忆诊所 神经心理学测验 医学 内科学 精神科 疾病
作者
Rui Tian,Yanxin Zhang,Fang Liu,Xinran Xue,Yutong Zhang,Zhuo Tian,Tingting Fang,Ruxue Fan,Yuan Li,Nan Zhang
出处
期刊:International Journal of Geriatric Psychiatry [Wiley]
卷期号:38 (3) 被引量:8
标识
DOI:10.1002/gps.5900
摘要

Abstract Objectives Cognitive and neuroimaging assessments are still the main clinical practice methods for screening and diagnosing vascular dementia (VaD) patients. This study aimed to establish the neuropsychological characteristics of mild‐to‐moderate subcortical ischaemic vascular dementia (SIVD) patients, find an optimal cognitive marker for differentiating them from Alzheimer's disease (AD) patients, and explore the correlation between cognitive function and total small vessel disease (SVD) burden. Methods SIVD ( n = 60) and AD ( n = 30) patients and cognitively unimpaired healthy controls (HCs; n = 30) were recruited from our longitudinal MRI AD and SIVD study (ChiCTR1900027943) and received a comprehensive neuropsychological assessment and a multimodal MRI scan. Cognitive performance and MRI SVD markers were compared between groups. Combined cognitive scores were established for differentiating between SIVD and AD patients. Correlations between cognitive function and total SVD scores were analysed in dementia patients. Results SIVD patients showed poorer performance in information processing speed and better performance in memory, language, and visuospatial function than AD patients, although all cognitive domains were impaired in both groups compared with HCs. Combined cognitive scores showed an area under the curve of 0.727 (95%CI 0.62–0.84, p < 0.001) for differentiating SIVD and AD patients. Auditory Verbal Learning Test recognition scores were negatively correlated with total SVD scores in SIVD patients. Conclusions Our results suggested that neuropsychological assessments, specifically combined tests including episodic memory, information processing speed, language and visuospatial ability, are useful in the clinical differentiation between SIVD and AD patients. Moreover, cognitive dysfunction was partly correlated with MRI SVD burden in SIVD patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
田様应助旧梦采纳,获得10
1秒前
mx发布了新的文献求助10
2秒前
寒天抒完成签到 ,获得积分10
3秒前
3秒前
QQ发布了新的文献求助10
4秒前
无情心情完成签到,获得积分10
5秒前
无情心情发布了新的文献求助10
7秒前
老大蒂亚戈应助潇湘雪月采纳,获得10
8秒前
打我呀发布了新的文献求助30
8秒前
9秒前
所所应助科研通管家采纳,获得10
9秒前
汉堡包应助科研通管家采纳,获得10
10秒前
MchemG应助科研通管家采纳,获得10
10秒前
YamDaamCaa应助科研通管家采纳,获得30
10秒前
852应助科研通管家采纳,获得10
10秒前
大模型应助科研通管家采纳,获得30
10秒前
MchemG应助科研通管家采纳,获得10
10秒前
完美世界应助科研通管家采纳,获得30
10秒前
情怀应助科研通管家采纳,获得10
10秒前
科研通AI5应助科研通管家采纳,获得10
10秒前
隐形曼青应助科研通管家采纳,获得10
10秒前
MchemG应助科研通管家采纳,获得10
10秒前
10秒前
李爱国应助深情的雁露采纳,获得10
10秒前
11秒前
盘尼西林发布了新的文献求助10
16秒前
幸福大白发布了新的文献求助10
16秒前
希望天下0贩的0应助李李采纳,获得10
17秒前
QQ完成签到,获得积分20
17秒前
17秒前
BiuBiu怪完成签到,获得积分10
19秒前
Dellamoffy完成签到,获得积分10
19秒前
20秒前
cnlt应助会撒娇的采蓝采纳,获得10
20秒前
海藻发布了新的文献求助10
22秒前
23秒前
盘尼西林完成签到,获得积分10
23秒前
yar应助JK采纳,获得10
25秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989406
求助须知:如何正确求助?哪些是违规求助? 3531522
关于积分的说明 11254187
捐赠科研通 3270174
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174