The behavior of the total carbon dioxide content in the atmosphere of the south of Western Siberia (48°–53° N, 60°– 90° E) has been studied using data from the orbital carbon observatories OCO-2 and OCO-3. OCO-2 data analysis was carried out for the period 2014-2021, OCO-3 results have been added to processing since 2019. To describe the seasonal cycle of CO2 content in the atmosphere of the region, we use an empirical model that was proposed for the interpretation of GOSAT satellite data and verified by the results of measurements of TCCON the global network of ground stations. It was found that for the studied period the increase rate of CO2 in the atmosphere of the region is about 2.48 ppm/year, and the amplitude of seasonal fluctuations is about 9.3 ppm. The possibility of applying satellite data with sufficient precision, coverage, and resolution to support of works on the carbon polygons in the south of Western Siberia was analyzed.