Temporomandibular disorders (TMD) are amongst the most common causes of orofacial pain. Hyperactivity of the lateral pterygoid muscle (LPM) is associated with the pathological mechanisms associated with TMD. Botulinum Toxin-A (BTX) injections into the LPM can be used as a treatment for TMD; however, a lack of clinical standardisation for this procedure can lead to adverse outcomes, especially when using anatomical landmark-based approaches.