Advancing Polyphenol-Based Nanomedicine for Inflammatory Bowel Disease: Challenges and Opportunities

炎症性肠病 纳米医学 炎症性肠病 医学 疾病 内科学 纳米技术 材料科学 纳米颗粒
作者
Liucan Wang,Guoqing Chen,Yang Yang,Chao Xu,Li Zhu,Hua Yang,Min Yu
出处
期刊:Journal of Inflammation Research [Dove Medical Press]
卷期号:Volume 17: 9889-9904
标识
DOI:10.2147/jir.s487942
摘要

Oxidative stress, characterized by excessive production of reactive oxygen species (ROS), is a critical factor in the progression of inflammatory bowel disease (IBD) and presents a potential therapeutic target. Anti-oxidant therapy, aimed at mitigating excessive ROS, is emerging as a cornerstone in IBD treatment. Nanomaterials with robust anti-oxidant properties offer promise by inhibiting inflammation through ROS scavenging, enhancing IBD therapeutic efficacy. Recent focus in ROS scavenging has centered on metal oxide nanoenzymes and polyphenol-based nanomaterials. The primary challenges are the catalytic efficiency of nanoenzymes and the functional integration of these nanomaterials with therapeutic agents. Polyphenols, natural plant extracts, have garnered significant interest due to their potent anti-oxidant properties and unique catechol groups that interact with biomolecules such as proteins and nucleic acids. The strong metal ion chelating ability of catechols enriches the structure and functionality of nanomaterials, improving the physicochemical properties of nanocarriers and enabling innovative designs of multifunctional drug delivery systems (DDSs). Research on polyphenol-based DDSs has expanded to include agents like epigallocatechin gallate, curcumin, resveratrol, tannic acid, and polydopamine. These nanocarriers and anti-oxidants, which incorporate polyphenols, have demonstrated potential anti-oxidant properties in novel DDSs as therapeutic agents to reduce inflammation and as essential components of drug carriers. This review focuses on the design and application of natural polyphenol-based anti-oxidant nanomaterials for IBD treatment, offering a comprehensive discussion on the use of polyphenols in DDSs and the potential challenges posed by their diverse roles in innovative drug delivery strategies, including their impact on the physical and chemical properties of DDSs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
yihaiqin完成签到 ,获得积分10
1秒前
轩辕剑身完成签到,获得积分0
1秒前
coolkid完成签到 ,获得积分0
2秒前
你怎么那么美完成签到,获得积分10
2秒前
游艺完成签到 ,获得积分10
5秒前
冬月完成签到 ,获得积分10
5秒前
薛乎虚完成签到 ,获得积分10
6秒前
7秒前
大胖完成签到,获得积分10
7秒前
野火197完成签到,获得积分10
11秒前
12秒前
量子星尘发布了新的文献求助10
15秒前
April完成签到,获得积分10
15秒前
周舟完成签到 ,获得积分10
18秒前
V_I_G完成签到 ,获得积分10
19秒前
nick完成签到,获得积分10
20秒前
高高高完成签到 ,获得积分10
23秒前
彪壮的亦瑶完成签到 ,获得积分10
24秒前
科研通AI2S应助科研通管家采纳,获得10
26秒前
Perry应助科研通管家采纳,获得60
26秒前
Akim应助科研通管家采纳,获得10
26秒前
鱼雷完成签到,获得积分10
27秒前
廿伊发布了新的文献求助10
29秒前
我是125完成签到,获得积分10
31秒前
依人如梦完成签到 ,获得积分10
32秒前
33秒前
PDIF-CN2完成签到,获得积分10
37秒前
雪雪完成签到 ,获得积分10
38秒前
39秒前
Willow完成签到,获得积分10
42秒前
研研研完成签到,获得积分10
43秒前
大橙子发布了新的文献求助10
45秒前
dejiangcj完成签到 ,获得积分10
46秒前
无味完成签到,获得积分10
47秒前
大气的尔蓝完成签到,获得积分10
48秒前
科研通AI5应助普鲁卡因采纳,获得10
49秒前
略略略完成签到 ,获得积分10
51秒前
zqlxueli完成签到 ,获得积分10
55秒前
无语的断缘完成签到,获得积分10
57秒前
hdx完成签到 ,获得积分10
58秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038128
求助须知:如何正确求助?哪些是违规求助? 3575831
关于积分的说明 11373827
捐赠科研通 3305610
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022