CineECG Repolarization Gradients Predict Acute Hemodynamic Response in CRT Patients

ABSTRACT Introduction A variable proportion of non‐responders to cardiac resynchronization therapy (CRT) warrants the search for new approaches to optimize the position of the left ventricular (LV) lead and the CRT device programming. CineECG is a novel ECG modality proposed for the spatial visualization and quantification of myocardial depolarization and repolarization sequences. Objective The present study aimed to evaluate CineECG‐derived parameters in different pacing modes and to test their associations with acute hemodynamic responses in CRT patients. Methods and Results CineECG was used to construct the average electrical path within the cardiac anatomy from the 12‐lead ECG. CineECG and LV dP/dt max were tested in 15 patients with nonischemic dilated cardiomyopathy and left bundle branch block (QRS: 170 ± 17 ms; LVEF: 26 ± 5.5%) under pacing protocols with different LV lead localizations. The CineECG‐derived path directions were computed for the QRS and ST‐T intervals for the anteroposterior (X h ), interventricular (Y h ), and apicobasal (Z h ) axes. In a multivariate linear regression analysis with adjustment for the pacing protocol type, the ST‐T path direction Y h was independently associated with the increase in dP/dt max during CRT, [regression coefficient 639.4 (95% confidence interval: 187.9–1090.9), p = 0.006]. In ROC curve analysis, the ST‐T path direction Y h was associated with the achievement of a 10% increase in dP/dt max (AUC: 0.779, p = 0.002) with the optimal cut‐off > 0.084 (left‐to‐right direction) with sensitivity 0.67 and specificity 0.92. Conclusion The acute hemodynamic response in CRT patients was associated with specific CineECG repolarization sequence parameters, warranting their further testing as potential predictors of clinical outcomes.