This paper aims to connect Stiegler’s reflections on theoretical computer science with his practical propositions for the design of digital technologies. Indeed, Stiegler’s theory of exosomatization implies a new conception of artificial intelligence, which is not based on an analogical paradigm (which compares organisms and machines, as in cybernetics, or which compares thought and computing, as in cognitivism) but on an organological paradigm, which studies the co-evolution of living organisms (individuals), artificial organs (tools), and social organizations (institutions). Such a perspective does not compare human capacities to machine performances but studies the way in which the evolution of material and technical supports affects and transforms psychological, cognitive or noetic faculties (intuition, memory, understanding, imagination, sensibility, reason, etc.), as well as the constitution of different kinds of knowledge. This new theoretical paradigm implies a new ‘design’ for digital technologies, which considers their social role and their impact on psychological, cognitive or noetic faculties.