自闭症谱系障碍
突触修剪
神经炎症
神经发育障碍
自闭症
神经科学
病因学
小胶质细胞
失调
心理学
肠道菌群
医学
精神科
免疫学
炎症
作者
Meng Jian,Lingliang Zhang,Yunwu Zhang
标识
DOI:10.1177/10738584241252576
摘要
Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder with onset in childhood. The molecular mechanisms underlying ASD have not yet been elucidated completely. Evidence has emerged to support a link between microglial dysfunction and the etiology of ASD. This review summarizes current research on microglial dysfunction in neuroinflammation and synaptic pruning, which are associated with altered transcriptomes and autophagy in ASD. Dysbiosis of gut microbiota in ASD and its correlation with microglial dysfunction are also addressed.
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