汽车T细胞治疗
淋巴瘤
T细胞
T细胞淋巴瘤
医学
癌症研究
细胞疗法
嵌合抗原受体
细胞
免疫学
生物
免疫系统
遗传学
作者
Metin Özdemirli,Thomas M. Loughney,Stefania Pittaluga,Joeffrey Chahine,Stefania Pittaluga,Stefania Pittaluga,Stefania Pittaluga,Philippe Armand,Stefania Pittaluga,Kenneth C. Anderson
标识
DOI:10.1056/nejmoa2401530
摘要
SummaryIndolent CD4+ cytotoxic chimeric antigen receptor (CAR) T-cell lymphoma involving the small intestine was diagnosed in a patient who had previously received ciltacabtagene autoleucel (cilta-cel) CAR T-cell therapy for treatment of myeloma. Targeted messenger RNA sequencing revealed the presence of CAR gene product in tumor cells. Whole-genome sequencing of samples of tumor and peripheral blood identified a single lentiviral insertion site within the second intron of the SSU72 gene. In addition, numerous genetic alterations that may have contributed to malignant transformation were identified in the tumor sample. (Funded by MedStar Georgetown University Hospital.)
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