Design, synthesis, and anticancer assessment of structural analogues of (E)-1-((3,4,5-trimethoxybenzylidene)amino)-4-(3,4,5-trimethoxyphenyl)imidazo[1,2-a]quinoxaline-2-carbonitrile (6b), an imidazo[1,2-a]quinoxaline-based non-covalent EGFR inhibitor

Two lead compounds, 5a and 5l, designed on an imidazo[1,2- a ]quinoxaline template, emerged as potent EGFR inhibitors and anti-lung cancer agents.