透明质酸
甘露糖
对偶(语法数字)
金属有机骨架
化学
输送系统
金属
自愈水凝胶
纳米技术
材料科学
化学工程
生物医学工程
高分子化学
有机化学
医学
艺术
文学类
吸附
解剖
工程类
作者
Hossein Poursadegh,Vahid Bakhshi,Mohammad Sadegh Amini‐Fazl,Zahra Adibag,Fahimeh Kazeminava,Siamak Javanbakht
标识
DOI:10.1016/j.ijbiomac.2024.133516
摘要
The recent challenge in enhancing the targeted delivery of anticancer drugs to cancer cells is improving the bioavailability and therapeutic efficacy of drug delivery systems while minimizing their systemic side effects. In this study, the MIL-88(Fe) metal-organic framework was synthesized using the in situ method in the presence of hydroxyapatite nanoparticles (HAP) toward the HAP/MIL-88(Fe) (HM) nanocomposite preparation. It was then functionalized with mannose (M) as an anticancer receptor through the Steglich esterification method. Various analyses confirmed the successful synthesis of MHM. For drug release investigation, 5-Fu was loaded into the MHM, which was then coated with a hyaluronic acid (HA) hydrogel film. Characterization analyses verified the structure of the resulting HA/5-Fu-MHM hydrogel film. In vitro drug release experiments showed that the release of 5-Fu drug from HA/5-Fu-MHM could be controlled with pH, reducing its release rate in the acidic environment of the stomach while increasing it in the intestinal environment. Cytotoxicity results of the HA/5-Fu-MHM hydrogel film against HT29 cancer cells showed enhanced cytotoxicity due to the mannose and hyaluronic acid in its structure, which triggers a dual-targeted drug delivery system. The obtained results indicate that the prepared hydrogel films can be a promising bio-platform for colon cancer treatment.
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