细胞周期
细胞分裂
细胞生长
细胞生物学
转移
功能(生物学)
癌症研究
肿瘤进展
细胞周期蛋白
细胞
细胞周期检查点
生物
癌症
遗传学
作者
Zhaoyu Wang,Minshijing Ren,Wei Liu,Jin Wu,Peng Tang
标识
DOI:10.1016/j.bbcan.2024.189147
摘要
The cell division cycle-associated protein (CDCA) family is important in regulating cell division. High CDCA expression is significantly linked to tumor development. This review summarizes clinical and basic studies on CDCAs conducted in recent decades. Furthermore, it systematically introduces the molecular expression and function, key mechanisms, cell cycle regulation, and roles of CDCAs in tumor development, cell proliferation, drug resistance, invasion, and metastasis. Additionally, it presents the latest research on tumor diagnosis, prognosis, and treatment targeting CDCAs. These findings are pivotal for further in-depth studies on the role of CDCAs in promoting tumor development and provide theoretical support for their application as new anti-tumor targets.
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