帕金森病
医学
疾病
重症监护医学
神经科学
心理学
内科学
作者
Qing Yin Zheng,Hanghang Liu,Yifan Gao,Guozhi Cao,Yusong Wang,Zhen Li
出处
期刊:Small
[Wiley]
日期:2024-02-22
被引量:2
标识
DOI:10.1002/smll.202311571
摘要
Abstract Parkinson's disease (PD) is currently the second most incurable central neurodegenerative disease resulting from various pathogenesis. As the “energy factory” of cells, mitochondria play an extremely important role in supporting neuronal signal transmission and other physiological activities. Mitochondrial dysfunction can cause and accelerate the occurrence and progression of PD. How to effectively prevent and suppress mitochondrial disorders is a key strategy for the treatment of PD from the root. Therefore, the emerging mitochondria‐targeted therapy has attracted considerable interest. Herein, the relationship between mitochondrial dysfunction and PD, the causes and results of mitochondrial dysfunction, and major strategies for ameliorating mitochondrial dysfunction to treat PD are systematically reviewed. The study also prospects the main challenges for the treatment of PD.
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