In this paper, a real-time monitoring system of human health data in a household environment is designed. The system applies Zigbee wireless communication technology to transmit real-time data and establishes family members' health records on the server. After processing by central processing unit(CPU), the system sends the temperature and heart rate data collected by the terminal to the coordinator and realizes real-time data monitoring through the serial port on the PC side. The system can be divided into a system microprocessor, digital system module, human-computer interaction module, signal acquisition module, and wireless communication module, etc., according to the human heart rate, blood oxygen, temperature, and other critical physiological parameters processing and analysis, and then real-time monitoring of the human body. System processor STM32F103C8T6 as the CPU, display module selected OLED; The MAX30102 sensor and Pulse sense sensor were selected for the physiological parameter acquisition system to collect the heart rate of the wrist and finger, respectively. After physiological parameters were collected, A/D transformation was further performed. Through the software and hardware design test of one terminal of the system, the system can accurately measure the physiological information of different patients. By comparing the data, the accuracy can reach 2%. It can be proved that the system has an excellent medical application prospect.