小胶质细胞
分形维数
分形
神经科学
神经元
分形分析
生物
计算机科学
生物系统
数学
炎症
免疫学
数学分析
作者
Audrey Karperien,Herbert F. Jelinek
出处
期刊:Advances in neurobiology
日期:2024-01-01
卷期号:: 149-172
被引量:2
标识
DOI:10.1007/978-3-031-47606-8_7
摘要
Microglia and neurons live physically intertwined, intimately related structurally and functionally in a dynamic relationship in which microglia change continuously over a much shorter timescale than do neurons. Although microglia may unwind and depart from the neurons they attend under certain circumstances, in general, together both contribute to the fractal topology of the brain that defines its computational capabilities. Both neuronal and microglial morphologies are well-described using fractal analysis complementary to more traditional measures. For neurons, the fractal dimension has proved valuable for classifying dendritic branching and other neuronal features relevant to pathology and development. For microglia, fractal geometry has substantially contributed to classifying functional categories, where, in general, the more pathological the biological status, the lower the fractal dimension for individual cells, with some exceptions, including hyper-ramification. This chapter provides a review of the intimate relationships between neurons and microglia, by introducing 2D and 3D fractal analysis methodology and its applications in neuron–microglia function in health and disease.
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