氧化应激
体内
GPX4
谷胱甘肽
神经毒性
药理学
医学
神经保护
海马体
化学
生物
毒性
生物化学
内科学
过氧化氢酶
生物技术
谷胱甘肽过氧化物酶
酶
作者
Yuhang Gong,Yanan Wang,Yanfeng Li,Fanglin Weng,Tong Chen,Ling He
摘要
Alzheimer's disease (AD) is a neurodegenerative disorder where oxidative stress, induced by ferroptosis, has been linked to neuronal damage and cognitive deficits. The objective of this study is to investigate if the potential therapeutic agent, Curculigoside (CUR), could ameliorate AD by inhibiting ferroptosis. The potential therapeutic targets, such as GPX4 and SLC7A11, were identified using weighted gene co-expression network analysis (WGCNA). Concurrently, CUR was also screened against these potential targets using various analytical methods. For the in vivo studies, intragastric administration of CUR significantly ameliorated cognitive impairment in AD model mice induced by scopolamine and okadaic acid (OA). In vitro, CUR protected neuronal cells by altering the levels of ferroptosis-related specific markers in OA and scopolamine-induced neurotoxicity. The administration of CUR through intragastric route significantly reduced the levels of AD-promoting factors (such as Aβ
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