Lewis Base Catalyzed C−S Bond Formation Through Methyl C(sp3)‐H Thiocyanation of Indoles

Abstract A Lewis base catalyzed C−S bond formation through thiocyanation of methyl C(sp 3 )−H bond is reported. The method involves a sequential chlorination and thiocyanation reaction. This simple yet effective protocol works with diverse array of indoles to furnish thiocyanated products in good yield (up to 85 %). The developed method is also applied for the synthesis of phercaptoline (hypotensive agent) and umifenovir (antiviral drug).