卤化
皂化
脱羧
区域选择性
化学
一锅法合成
生产(经济)
有机化学
催化作用
经济
宏观经济学
作者
K.B. Brown,Yun Huang,Kevin M. Knopf,Bryan Li,Martha A. Ornelas,Rebecca B. Watson
标识
DOI:10.1021/acs.oprd.3c00309
摘要
Multiple methods for the preparation of 3,5-dibromopyrazole are described. While 3,5-dibromopyrazole is readily available on a kilogram scale, an internal demand facilitated the need to expand the vendor pool, with an overall goal of lowering cost. To pursue this goal, we focused on developing synthetic methods in the operating temperature range of −20 to 120 °C to remove production process constraints and explored the option of a continuous flow procedure for regioselective dehalogenation of 3,4,5-tribromopyrazole. An alternative method that started with bromination of pyrazole-3-carboxylate ester, followed by one-pot saponification and decarboxylation, was found to be efficient as well.
科研通智能强力驱动
Strongly Powered by AbleSci AI