纳米技术
生物结合
药物输送
生化工程
计算机科学
计算生物学
工程伦理学
化学
工程类
材料科学
生物
作者
Sheryl Wang,Hong Wang,Andrew A. Drabek,Wenwen Sha Smith,Yang Yang,Zhaohua Huang
标识
DOI:10.1021/acs.molpharmaceut.3c00735
摘要
Antibody-targeted lipid nanoparticles (Ab-LNPs) are rapidly gaining traction as multifaceted platforms in precision medicine, adept at delivering a diverse array of therapeutic agents, including nucleic acids and small molecules. This review provides an incisive overview of the latest developments in the field of Ab-LNP technology, with a special emphasis on pivotal design aspects such as antibody engineering, bioconjugation strategies, and advanced formulation techniques. Furthermore, it addresses critical chemistry, manufacturing, and controls (CMC) considerations and thoroughly examines the in vivo dynamics of Ab-LNPs, underscoring their promising potential for clinical application. By seamlessly blending scientific advancements with practical industrial perspectives, this review casts a spotlight on the burgeoning role of Ab-LNPs as an innovative and potent tool in the realm of targeted drug delivery.
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