自噬
内吞作用
功能(生物学)
PI3K/AKT/mTOR通路
细胞生物学
化学
ULK1
激酶
神经科学
生物
信号转导
细胞
生物化学
蛋白激酶A
细胞凋亡
安普克
作者
Yuan Liu,Qilin Yang,Siwei Chen,Zixiang Li,Leilei Fu
标识
DOI:10.1016/j.ejmech.2023.115467
摘要
VPS34 is well-known to be the unique member of the class III phosphoinositide 3-kinase (PI3K) family, forming VPS34 complex 1 and complex 2, which are involved in several key physiological processes. Of note, VPS34 complex 1 is an important node of autophagosome generation, which controls T cell metabolism and maintains cellular homeostasis through the autophagic pathway. And, VPS34 complex 2 is involved in endocytosis as well as vesicular transport, and is closely related to neurotransmission, antigen presentation and brain development. Due to the two important biological functions of VPS34, its dysregulation can lead to the development of cardiovascular disease, cancer, neurological disorders, and many types of human diseases by altering normal human physiology. Thus, in this review, we not only summarize the molecular structure and function of VPS34, but demonstrate the relationships between VPS34 and human diseases. Moreover, we further discuss the current small molecule inhibitors targeting VPS34 based upon the structure and function of VPS34, which may provide an insight into the future targeted drug development.
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