免疫系统
髓样
免疫检查点
获得性免疫系统
先天免疫系统
髓系细胞
CXCL10型
癌症研究
免疫学
生物
趋化因子
免疫疗法
作者
Ruochen Du,Jianzhong Zhang,Rimas V. Lukas,Shashwat Tripathi,Jared T. Ahrendsen,Michael A. Curran,Crismita Dmello,Peng Zhang,Roger Stupp,Ganesh Rao,Amy B. Heimberger
出处
期刊:Neuro-oncology
[Oxford University Press]
日期:2024-09-16
标识
DOI:10.1093/neuonc/noae193
摘要
Abstract The field of immunology has traditionally focused on immune checkpoint modulation of adaptive immune cells. However, many malignancies such as glioblastoma are mostly devoid of T cells and rather are enriched with immunosuppressive myeloid cells of the innate immune system. While some immune checkpoint targets are shared between adaptive and innate immunity, myeloid-specific checkpoints could also serve as potential therapeutics. To better understand the impact of immune checkpoint blockade on myeloid cells, we systematically summarize the current literature focusing on the direct immunological effects of PD-L1/PD-1, CD24/Siglec-10, collagen/LAIR-1, CX3CL1/CX3CR1, and CXCL10/CXCR3. By synthesizing the molecular mechanisms and the translational implications, we aim to prioritize agents in this category of therapeutics for glioblastoma.
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