孟德尔随机化
牙周炎
医学
内科学
生命银行
全国健康与营养检查调查
体质指数
因果关系(物理学)
生物信息学
基因型
生物
环境卫生
遗传学
人口
物理
量子力学
遗传变异
基因
作者
Lin Song,Yifan Wang,Qiwen Zheng,Wenjing Li
摘要
Abstract Aim This study aimed to investigate the association of periodontitis with biological aging and to assess potential causality using Mendelian randomization (MR). Methods A cross‐sectional study with 9558 participants from the National Health and Nutrition Examination Survey (2009–2014) was conducted. Age acceleration (BioAgeAccel and PhenoAgeAccel) was calculated from clinical biomarkers and their discrepancies with chronological age. Two‐sample MR analysis was performed using data from a large‐scale genome‐wide association study and UK Biobank. Results Periodontitis was associated with increased biological aging, with 0.57‐year (95% CI: 0.28–0.86, p < .001) increases in BioAgeAccel and 0.41‐year (95% CI: 0.04–0.78, p = .034) increases in PhenoAgeAccel. Subgroup analysis found significantly stronger associations in males for BioAgeAccele ( P INTERACTION = .006), and pronounced associations in young adults ( p interaction = .023), individuals with normal body mass index ( p interaction = .015), and current smokers ( p interaction = .016) for PehonAgeAccel. MR analysis did not provide strong evidence for a causal effect of periodontitis on biological aging (BioAgeAccel: IVW β = 0.008, 95% CI: −0.018 to 0.034, p = .553 and PhenoAgeAccel: IVW β = 0.016, 95% CI: −0.042 to 0.074, p = .585). Conclusion This study identified the association of periodontitis and its severity with accelerated aging, suggesting periodontal health could be a possible method in personalized preventive and therapeutic strategies of biological aging.
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