Right ventricular remodelling and long-term survival after pulmonary endarterectomy versus balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension

医学 心脏病学 内科学 肺动脉高压 肺动脉 血管成形术 波生坦 气球 慢性血栓栓塞性肺高压 内皮素受体 受体
作者
Håvard Ravnestad,Klaus Murbræch,Eyvind Gjønnæss,Rune Andersen,Narve Moe,S Birkeland,Morten Svalebjørg,Per Snorre Lingaas,Einar Gude,Lars Gullestad,John‐Peder Escobar Kvitting,Kaspar Broch,Arne K. Andreassen
出处
期刊:Heart [BMJ]
卷期号:: heartjnl-324243
标识
DOI:10.1136/heartjnl-2024-324243
摘要

Background Pulmonary endarterectomy (PEA) is the treatment of choice for chronic thromboembolic pulmonary hypertension (CTEPH), while balloon pulmonary angioplasty (BPA) is an alternative for inoperable patients. We aimed to compare right ventricular (RV) remodelling and late survival after PEA and BPA. Methods In this prospective observational cohort study, we performed echocardiography at baseline and follow-up in patients with CTEPH treated with PEA (n=54) or BPA (n=44) between 2011 and 2022. Results Follow-up echocardiography was performed at 5 months (IQR 4–7) after PEA and 3 months (IQR 2–4) after the last BPA. Both groups showed significant improvements in left ventricular end-systolic eccentricity index, RV basal diameter and RV fractional area change (RV FAC). Tricuspid regurgitation pressure decreased by 26±18 mm Hg after PEA and 13±21 mm Hg after BPA (p=0.02 for between-group difference). Tricuspid annular systolic excursion (TAPSE) decreased by 4±5 mm after PEA but increased by 1±4 mm after BPA (p<0.001). The TAPSE/systolic pulmonary artery pressure ratio improved similarly in both groups. Five-year survival was 96% (95% CI 86% to 99%) for PEA and 79% (95% CI 61% to 89%) for BPA (p=0.25). Change in RV FAC was an independent predictor of survival (HR 0.9, 95% CI 0.82 to 0.99, p=0.03). Conclusions Both PEA and BPA led to significant RV reverse remodelling, with no clear evidence of a difference in survival rates. Improvement in RV function, particularly RV FAC, was associated with better outcomes, highlighting the importance of RV recovery in CTEPH treatment.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
李健的粉丝团团长应助thia采纳,获得10
1秒前
1秒前
kaiko发布了新的文献求助20
1秒前
1秒前
2秒前
2秒前
鲤鱼初柳发布了新的文献求助10
2秒前
4秒前
NexusExplorer应助文静寄琴采纳,获得10
4秒前
ling完成签到 ,获得积分10
5秒前
happiness完成签到 ,获得积分10
5秒前
tonghau895完成签到 ,获得积分10
5秒前
5秒前
6秒前
7秒前
梅仑西西发布了新的文献求助20
7秒前
萧水白应助lovekobe采纳,获得10
7秒前
迷路海蓝应助lovekobe采纳,获得10
7秒前
传奇3应助lovekobe采纳,获得10
7秒前
7秒前
深情安青应助lovekobe采纳,获得10
7秒前
铭铭应助lovekobe采纳,获得10
7秒前
去看海嘛应助lovekobe采纳,获得10
7秒前
超帅路灯应助lovekobe采纳,获得10
7秒前
去看海嘛应助lovekobe采纳,获得10
7秒前
不配.应助lovekobe采纳,获得10
7秒前
星辰大海应助lovekobe采纳,获得10
8秒前
李爱国应助blUe采纳,获得10
8秒前
Lucas应助xuhang采纳,获得10
8秒前
爆米花应助周周采纳,获得10
8秒前
没有好的昵称可以取完成签到 ,获得积分10
8秒前
kieerw发布了新的文献求助30
8秒前
Akim应助betterzhu采纳,获得10
8秒前
wwf完成签到 ,获得积分10
9秒前
9秒前
霜揽月发布了新的文献求助10
9秒前
hyelachan发布了新的文献求助20
10秒前
852应助穿多点采纳,获得10
10秒前
10秒前
逆熵完成签到 ,获得积分10
11秒前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3155576
求助须知:如何正确求助?哪些是违规求助? 2806779
关于积分的说明 7870685
捐赠科研通 2465047
什么是DOI,文献DOI怎么找? 1312118
科研通“疑难数据库(出版商)”最低求助积分说明 629877
版权声明 601892