化学发光
鲁米诺
谷胱甘肽
激进的
催化作用
纳米颗粒
化学
热液循环
核化学
材料科学
无机化学
纳米技术
化学工程
有机化学
酶
工程类
作者
Xiaohu Ma,Peiyu Jiang,Jingbo Geng,Xinyi Li,Yan Jin,Baoxin Li,Wei Liu
出处
期刊:Research Square - Research Square
日期:2024-07-29
标识
DOI:10.21203/rs.3.rs-4678477/v1
摘要
Abstract In this study, a chemiluminescence (CL) method for determination of glutathione (GSH) was developed with magnetic nanoparticle-decorated metal organic frameworks (Fe3O4 NPs@Cu-TATB). The composite material was synthesized via a hydrothermal method and glutathione (GSH) can be tested by both visual and chemiluminescence (CL) methods. The synthesized Fe3O4 NPs@Cu-TATB exhibited excellent catalytic activity in the luminol-H2O2 CL system. The mechanism revealed that three types of oxygen-containing radicals (ROS) was generated in this system. As GSH can reduce the catalytic effect of generated ROS radicals, the inhibiting CL signal was produced in the Fe3O4 NPs@Cu-TATB-luminol-H2O2 system. Based on the established CL system, the detection limits for GSH using CL and visual methods were found to be 0.3 µM and 0.7 µM, respectively. This low-cost and convenient detection method can be applied to the analysis of GSH content in human blood.
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