Efficient drug delivery to hypoxic tumors using thermosensitive liposomes with encapsulated anti-cancer drug under high intensity pulsed ultrasound

药物输送 阿霉素 热疗 高强度聚焦超声 药品 化疗 癌症研究 脂质体 药理学 癌细胞 医学 靶向给药 癌症 生物医学工程 超声波 材料科学 外科 纳米技术 内科学 放射科
作者
Pouya Namakshenas,Afsaneh Mojra
出处
期刊:International Journal of Mechanical Sciences [Elsevier BV]
卷期号:237: 107818-107818 被引量:18
标识
DOI:10.1016/j.ijmecsci.2022.107818
摘要

Poor half-life, short circulation, systemic toxicity, insufficient accumulation, and ultimately weak therapeutic response are the most important obstacles in the conventional chemotherapy. Thermosensitive liposomes (TSLs) with encapsulated anti-cancer drug doxorubicin combined with high intensity focused ultrasound (HIFU) has the potential to overcome the shortcomings of conventional chemotherapy through targeted drug delivery. In the HIFU-TSL drug delivery system, complex physicochemical and biological processes are involved; however, many works in this field suffer from a comprehensive analysis. Regarding this, the present study has the novelty of developing an advanced multi-physical and multi-compartment model to simulate the complex processes in conventional and TSL-mediated chemotherapy paired with HIFU-induced hyperthermia. Elaborating the determinant role of tumor microenvironment is another novelty, which was underrepresented in earlier investigations and is noticed in our study through the modeling of hypoxic region. Additionally, unlike previous studies that used the classical bio-heat transfer model, this study has innovation in considering the thermal inertia as well as microstructural interactions in the bio-heat transfer equation. Last by not the least, many researchers evaded the harms of continuous irradiation, which in the present work is replaced by pulsed ultrasound as an emerging method for thermal necrosis and mild hyperthermia. The results reveal that the hypoxic region prevents efficient drug delivery due to the disruption of microvascular network and reduces chemotherapy-induced cell death. A comparison between targeted drug delivery and conventional chemotherapy suggests that TSL-mediated drug delivery leads to increased cell death by more than 100% by providing high circulation time and improved bioavailability. Besides this, increasing the acoustic power (from 3 to 8.7 W) leads to a desirable achievement, which is thermal necrosis of central tumor region and high fraction of killed cells (FKCs). The FKCs in the proposed HIFU-TSL system reaches about 58% (3 W), 60% (4.1 W), 70% (7 W), and 78% (8.7 W) at 24 h after TSL-doxorubicin administration, while this value is about 30% in the conventional chemotherapy. In conclusion, this study confirms the benefits of HIFU-TSL drug delivery system. This method has the potential to be used as a targeted drug delivery system to improve anti-cancer drug efficacy, while considerably prevents the normal tissue damage.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
忒寒碜完成签到,获得积分10
3秒前
7秒前
XU博士完成签到,获得积分10
9秒前
哭泣青烟完成签到 ,获得积分10
10秒前
roundtree完成签到 ,获得积分0
14秒前
等待谷南完成签到,获得积分10
17秒前
Alan完成签到 ,获得积分10
20秒前
xdc完成签到,获得积分10
22秒前
量子星尘发布了新的文献求助10
23秒前
依依完成签到 ,获得积分0
32秒前
MISSIW完成签到,获得积分10
33秒前
HHHAN发布了新的文献求助10
36秒前
胡胡完成签到 ,获得积分10
37秒前
火星上小土豆完成签到 ,获得积分10
47秒前
杰尼龟的鱼完成签到 ,获得积分10
51秒前
安然完成签到 ,获得积分10
52秒前
张希伦完成签到 ,获得积分10
52秒前
任性翠安完成签到 ,获得积分10
56秒前
dong完成签到 ,获得积分10
58秒前
神说完成签到,获得积分0
1分钟前
量子星尘发布了新的文献求助10
1分钟前
Aimee完成签到 ,获得积分10
1分钟前
徐彬荣完成签到,获得积分10
1分钟前
研友_8yN60L完成签到,获得积分10
1分钟前
搜集达人应助科研通管家采纳,获得10
1分钟前
光亮的自行车完成签到 ,获得积分10
1分钟前
李东东完成签到 ,获得积分10
1分钟前
王多肉完成签到,获得积分10
1分钟前
Iiiilr完成签到 ,获得积分10
1分钟前
杨幂完成签到,获得积分10
1分钟前
1分钟前
hellokitty完成签到,获得积分10
1分钟前
1分钟前
小四发布了新的文献求助10
1分钟前
1分钟前
西瓜完成签到 ,获得积分10
1分钟前
包容的忆灵完成签到 ,获得积分10
1分钟前
高兴尔冬发布了新的文献求助10
1分钟前
xiang完成签到 ,获得积分0
1分钟前
小四完成签到,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038039
求助须知:如何正确求助?哪些是违规求助? 3575756
关于积分的说明 11373782
捐赠科研通 3305574
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022