Sex differences in the association between nonalcoholic fatty liver disease and Parkinson's disease

非酒精性脂肪肝 医学 内科学 危险系数 置信区间 脂肪肝 人口 风险因素 疾病 帕金森病 胃肠病学 环境卫生
作者
Su‐Min Jeong,Han Rim Lee,Wooyoung Jang,Dahye Kim,Jung Eun Yoo,Keun Hye Jeon,Sang‐Man Jin,Kyungdo Han,Dong Wook Shin
出处
期刊:Parkinsonism & Related Disorders [Elsevier BV]
卷期号:93: 19-26 被引量:10
标识
DOI:10.1016/j.parkreldis.2021.10.030
摘要

The association between nonalcoholic fatty liver disease (NAFLD) and Parkinson's disease (PD) remains uncertain. This study sought to assess the sex-specific association between NAFLD and PD risk considering that sex is an important factor in both conditions.We included 2,651,169 men and 2,998,904 women (≥40 years of age) who underwent health examinations in 2009 using database of the Korean National Health Insurance Service. To define NAFLD, the Fatty Liver Index (FLI) was used and a score of at least 60 points was regarded as suggesting the presence of NAFLD. Cox proportional hazards analyses were performed to evaluate the association between the presence of NAFLD/each component of FLI and the risk of PD. All analyses were stratified by sex.The median follow-up duration was 7.3 years in both men and women. Of the total study population, 23,233 patients with PD (10,578 men and 12,655 women) were identified. Among men, a decreased risk of PD was observed in those with NAFLD [adjusted hazard ratio (aHR): 0.86, 95% confidence interval (CI): 0.82-0.91]. In contrast, among women, an increased risk of PD was observed in those with NAFLD (aHR: 1.09, 95% CI: 1.02-1.16). This different association according to sex was more prominent among younger participants but was not significant in the old age group.NAFLD defined by FLI is differently associated with the risk of PD by sex (i.e., low risk of PD in men with NAFLD vs. high risk of PD in women with NAFLD).
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